ABSTRACT
PURPOSE: To estimate the prevalence of co-prescribing contraindicated drugs for elderly patients in Busan. METHODS: We used the Health Insurance Review Agency (HIRA) claims database. Study population consisted of elderly patients who visited clinics or hospitals in Busan metropolitan city from January 1, 2000 to December 31, 2001. Contraindicated drugs were defined as 162 combinations of contraindicated drugs announced by the Korea Ministry of Health and Welfare in 2004. The co-prescription of contraindicated drugs was defined as prescribing two or more contraindicated drugs in combination in the same prescription. The prevalence of co-prescribing contraindicated drugswas estimated as proportion of co-prescribed patients out of the study patients. We estimated and age-adjusted prevalence and its 95% confidence interval of co-prescription of contraindicated drugs among the elderly patients in Korean population in 2001. RESULTS: The study elderly patients were 262,952 with 2,483,227 prescriptions. Among the study patients 1,208 (4.6%) were prescribed contraindicated drugs in combination. A total of 16,255 patients were estimated as the number of co-prescribed patients among the Korean elderly in 2001. Age-standardized prevalence of co-prescription to the Korean elderly was estimated to be 45 per 10,000 persons. The most frequently prescribed combinations were cisapride & amitriptyline, roxithromycin & ergoloid mesylate, and terfenadine & erythromycin, and the frequency were 325 (16.8%), 149 (7.7%), and 132 (6.8%),respectively. CONCLUSIONS: The contraindicated drugs were co-prescribed to the elderly patients in Korea. Many of these co-prescriptions should be avoided if unnecessary. The patients should be carefully monitored if they were inevitably prescribed the contraindicated drugs.
Subject(s)
Aged , Humans , Amitriptyline , Cisapride , Drug Combinations , Drug Utilization Review , Ergoloid Mesylates , Erythromycin , Insurance, Health , Korea , Prescriptions , Prevalence , Roxithromycin , TerfenadineABSTRACT
<p><b>OBJECTIVE</b>To observe the clinical effect of Yuantong Capsule (YTC) in treating vascular dementia (VD).</p><p><b>METHODS</b>Eighty-three patients of VD were randomized on ratio of 2:1 into two groups, the 54 patients in the treated group were treated with YTC orally administered, 3 times a day, 1 capsule in each time. The remaining 29 patients in the control group were treated with Hydergine orally, 3 times a day, 2 mg in each time. The therapeutic course for both groups was 2 months.</p><p><b>RESULTS</b>The therapeutic effect in the treated group was significantly better than that in the control group, significant difference (P < 0.05 or P < 0.01) was shown in comparison of the two groups in terms of the mini-mental state examination (MMSE) and activity of daily living (ADL) test, symptoms scoring, total effective rate, and laboratory indexes findings.</p><p><b>CONCLUSION</b>The therapeutic effect of YTC in treating VD was obvious.</p>
Subject(s)
Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Capsules , Dementia, Vascular , Drug Therapy , Drug Therapy, Combination , Drugs, Chinese Herbal , Therapeutic Uses , Ergoloid Mesylates , Therapeutic Uses , Nootropic Agents , Therapeutic Uses , PhytotherapyABSTRACT
Los autores presentan su experiencia clínica en el manejo de la hipoacusia súbita idiopática (HS) en un trabajo prospectivo realizado entre los años 1980 y 1998. En 53 pacientes con enfermedad, estudiaron sus características clínicas más relevantes y los exámenes de laboratorio más útiles. En este análisis, se concluye que en la gran mayoría de las HSI, no se puede establecer una etiología, y que la tardanza en el tratamiento, la aparición de vértigo en forma concomitante y la hipoacusia severa son síntomas ominosos. En su estudio, los autores establecen distintos grupos según el tipo de curva audiométrica (ascendente, plana y descendente), buscando diferencias de comportamiento. En relación al tratamiento, los autores establecieron tres grupos aleatorios que fueron tratados con vasodilatadores, corticoides o vitaminas. En el trabajo, se puedo establecer que los mejores resultados se obtuvieron con la corticoterapia en todos los tipos de curva audiométrica
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Hearing Loss, Sensorineural/diagnosis , Hearing Loss, Sudden/diagnosis , Audiometry , Methylprednisolone/therapeutic use , Vertigo/etiology , Prospective Studies , Ergoloid Mesylates/therapeutic use , Vitamin B Complex/therapeutic use , Age Distribution , Hearing Loss, Sensorineural/etiology , Hearing Loss, Sensorineural/drug therapy , Signs and Symptoms , Hearing Loss, Sudden/etiology , Hearing Loss, Sudden/drug therapyABSTRACT
This study was done on thirty adult febrile patients with different age. weight and sex and with different infectious aetiologies to evaluate the effect of [modified lytic cocktail mixture] a combination of promazine, pethidine and hydergine to assess their role on hyperpyrexia The results showed that the lytic cooctkail have significant effect on hyperpyrexia and that the combination of promazine, pethidine and hydergine was very excellent in lowering body temperature in this type of fever in short time [8 +/- 1.5 hours] and may be useful when urgent need to decrease body temperature is desired. They also decreased the PCO2, with no effect on haemodynamics and significant improvement in state of body oxygenation
Subject(s)
Humans , Male , Female , Promazine , Meperidine , Ergoloid Mesylates , Drug CombinationsABSTRACT
Se realizaron estudios para determinar la influencia de diferentes factores: el efecto de varios solventes del pH, la hermeticidad del envase y la adicion de un agente antioxidante con el proposito de recomendar laformulacion adecuada del producto. SE utilizo la cromatografia liquida de alta resolucion con metodo analitico en dichos estudios, la especificidad del mismo se comprobo en los ensayos previos. Como resultado se recomienda emplear en la formulacion de mesilato de dihidroergotoxina, gotas orales, glicerina o etanol como solventes, ajustar el pH en el intervalo 4,5 y 5,5, utilizar un envase hermetico y anadir tiourea como agente antioxidante
Subject(s)
Administration, Oral , Chemistry, Pharmaceutical , Chromatography, High Pressure Liquid , Ergoloid MesylatesABSTRACT
Se hace un estudio del uso del Methergin, medicamento derivado del cornezuelo de zenteno. La sensibilidad del útero a los alcaloides del cornezuelo de zenteno es variable, dependiendo especificamente del grado de madurez y la etepa de gestación.
Subject(s)
Humans , Female , Pregnancy , Parturition , Labor, Induced , Ergoloid Mesylates/therapeutic use , Ergoloid Mesylates/pharmacology , Oxytocics/adverse effects , Oxytocics/administration & dosageABSTRACT
The clinical state with EEG pattern similar to interval discharge of epileptics is named as latent epilepsy, which does not necessarily mean that the patient will develop epilepsy later. However, since there is possibility of developing epilepsy on later date, antiepileptic mainly dilantin was tried to control the abnormal EEG. Since January to October 1985, total 580 headache cases with more than moderately abnormal EEG visited the Neurology Clinic. Among them 162 cases with interval seizure pattern (ISP) of epilepsy were selected for the study. The main ISP was 1. diffuse theta and/or delta bursts and 2. spikes. Since the study in only analysis of clinical treatment of 162 cases without previous planning based on financial aid, about 30% of the patients did not return after the 1st EEG examination, in 42% failed to follow the EEG after the treatment and only remaining 28% of the cases were studied. Among 29 patients who were treated with Dilantin 100mg tid po, 16 improved and 13 not. Of the 13, 4 showed partial improvement and partial progression. Case1. In 4 weeks of antiepileptic therapy (AR), spikes disappeared but in 2 months developed bursts. Case2. In 17days of AR, spikes and bursts disappeared but in 3 months bursts reccured. Case3. In 1 week of AR, bursts disappeared but spikes developed. Case4. In 3 months of AR, no change of spikes and bursts and she discontinued the AR. In 6 months she developed grandma seizure. Eighteen cases, treated with other drugs except antiepileptics, all showed improvement. The other drugs were vincaprol, polygammalon, aronamin, ATP and hydergine. The improved cases had spikes more often than theta bursts. In view of the small number of the cases due to dropping most patients out of present study, it is considered meaningless to perform statistical analysis. Further well planned study with more patients is to be expected.
Subject(s)
Humans , Adenosine Triphosphate , Anticonvulsants , Electroencephalography , Epilepsy , Ergoloid Mesylates , Headache , Neurology , Phenytoin , SeizuresABSTRACT
Se estudian 26 pacientes divididos en tres grupos de acuerdo con su enfermedad de base, se utilizó un vasodilatador, el ergocomb, por vía intraarterial (femoral), valorando su efectividad por pruebas hemodinámicas. Ambas pruebas se realizaron antes y 15 minutos después de la administración del medicamento, obteniéndose diferentes resultados para los 3 grupos indicados. Se concluye que el ergocomb puede ser un agente de valor en el tratamiento médico de la insuficiencia arterial crónica de los miembros, por lo que se deben efectuar investigaciones posteriores con una mayor casuística, que permita confirmar esta posibilidad